In POI, HT is used to relieve symptoms and prevent osteoporosis.

In POI, HT is used to relieve symptoms and prevent osteoporosis.

• A. For fertility preservation
• B. For symptom relief and osteoporosis prevention
• C. For acne control
• D. Not used

Answer: (B)

In premature ovarian insufficiency, estrogen levels drop, which leads to hot flashes, vaginal dryness and atrophy, sleep and mood disturbances, and rapid bone loss. Hormone therapy provides the missing estrogen to relieve these vasomotor and genitourinary symptoms and to protect bone mineral density, reducing future osteoporosis risk. If a uterus is present, adding a progestin is important to prevent endometrial hyperplasia from the estrogen. The therapy is typically continued until the age at which natural menopause would occur to counteract the ongoing consequences of estrogen deficiency. It isn’t about fertility, and other unrelated issues like acne aren’t addressed by this approach, so the primary purpose is symptom relief plus osteoporosis prevention.

In premature ovarian insufficiency, estrogen levels drop, which leads to hot flashes, vaginal dryness and atrophy, sleep and mood disturbances, and rapid bone loss. Hormone therapy provides the missing estrogen to relieve these vasomotor and genitourinary symptoms and to protect bone mineral density, reducing future osteoporosis risk. If a uterus is present, adding a progestin is important to prevent endometrial hyperplasia from the estrogen. The therapy is typically continued until the age at which natural menopause would occur to counteract the ongoing consequences of estrogen deficiency. It isn’t about fertility, and other unrelated issues like acne aren’t addressed by this approach, so the primary purpose is symptom relief plus osteoporosis prevention.