In sequential therapy, progestogen is taken for how many days per month typically?

In sequential therapy, progestogen is taken for how many days per month typically?

• A. 5-10 days per month
• B. 20-24 days per month
• C. 28 days per month
• D. 10-14 days per month

Answer: (D)

Sequential therapy keeps estrogen going but adds progestogen for a limited part of each month. The progestogen is given for about 10–14 days to oppose the estrogen-driven proliferation of the endometrium and to create a regular withdrawal bleed. This duration provides enough endometrial protection without turning into continuous progestin exposure, which would lessen or remove the monthly bleed and alter bleeding patterns. If progestogen were used for a longer stretch (20–24 or 28 days), it would resemble continuous combined therapy and reduce the likelihood of a predictable monthly bleed. A shorter window (5–10 days) may not give adequate endometrial protection. So, 10–14 days per month is the typical and best-balanced length.

Sequential therapy keeps estrogen going but adds progestogen for a limited part of each month. The progestogen is given for about 10–14 days to oppose the estrogen-driven proliferation of the endometrium and to create a regular withdrawal bleed. This duration provides enough endometrial protection without turning into continuous progestin exposure, which would lessen or remove the monthly bleed and alter bleeding patterns. If progestogen were used for a longer stretch (20–24 or 28 days), it would resemble continuous combined therapy and reduce the likelihood of a predictable monthly bleed. A shorter window (5–10 days) may not give adequate endometrial protection. So, 10–14 days per month is the typical and best-balanced length.